Executive Summary - Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity
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چکیده
Toxicity testing is conducted to determine the potential human health hazards of chemicals and products. Acute systemic toxicity testing is used to properly classify and appropriately label materials with regard to their lethality potential in accordance with established regulatory requirements (49 CFR 173; 16 CFR 1500; 29 CFR 1910; 40 CFR 156). Non-lethal parameters may also be evaluated in acute systemic toxicity studies to identify potential target organ toxicity, toxicokinetic parameters, and dose-response relationships. While animals are currently used to evaluate acute toxicity, recent studies suggest that in vitro methods may also be helpful in predicting acute toxicity.
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